Moshe Laudon Selected Research

N- (2- (5- methoxy- indol- 3- yl)- ethyl)- 4- oxo- 4H- pyran- 2- carboxamide

10/2022	Chronic Piromelatine Treatment Alleviates Anxiety, Depressive Responses and Abnormal Hypothalamic-Pituitary-Adrenal Axis Activity in Prenatally Stressed Male and Female Rats.
1/2018	Melatonin Receptor Agonist Piromelatine Ameliorates Impaired Glucose Metabolism in Chronically Stressed Rats Fed a High-Fat Diet.
10/2017	Neu-P11, a novel MT1/MT2 agonist, reverses diabetes by suppressing the hypothalamic-pituitary-adrenal axis in rats.
5/2016	Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice.
1/2016	Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice.
1/2016	Piromelatine ameliorates memory deficits associated with chronic mild stress-induced anhedonia in rats.
12/2015	Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models.
10/2014	Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain.
3/2014	Piromelatine, a novel melatonin receptor agonist, stabilizes metabolic profiles and ameliorates insulin resistance in chronic sleep restricted rats.
2/2014	Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.

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Moshe Laudon Research Topics

Disease

16	Sleep Initiation and Maintenance Disorders (Insomnia) 10/2022 - 12/2003
7	Insulin Resistance 01/2018 - 04/2009
6	Sleep Wake Disorders 09/2014 - 01/2004
4	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 06/2013
3	Inflammation (Inflammations) 01/2017 - 07/2013
3	Weight Gain 03/2014 - 04/2009
2	Type 2 Diabetes Mellitus (MODY) 01/2018 - 10/2017
2	Glucose Intolerance 01/2018 - 10/2017
2	Body Weight (Weight, Body) 01/2018 - 04/2009
2	Hyperglycemia 01/2018 - 10/2017
2	Cognitive Dysfunction 01/2016 - 06/2013
2	Stroke (Strokes) 12/2015 - 02/2002
2	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2011 - 12/2007
2	Hypertension (High Blood Pressure) 01/2011 - 10/2006
1	Obesity 10/2017
1	Neuroblastoma 01/2017
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Wounds and Injuries (Trauma) 01/2017
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2016
1	Colitis 05/2016
1	Ulcer 05/2016
1	Seizures (Absence Seizure) 01/2016
1	Memory Disorders (Memory Loss) 01/2016
1	Epilepsy (Aura) 01/2016
1	Anhedonia 01/2016
1	Brain Ischemia (Cerebral Ischemia) 12/2015
1	Infarction (Infarctions) 12/2015
1	Hyperalgesia 10/2014
1	Neuralgia (Stump Neuralgia) 10/2014
1	Pain (Aches) 02/2014
1	Abdominal Pain (Pain, Abdominal) 02/2014
1	Visceral Pain 02/2014
1	Pneumonia (Pneumonitis) 07/2013
1	Emphysema 07/2013
1	Chronic Obstructive Pulmonary Disease (COPD) 07/2013
1	Chronic Bronchitis 07/2013
1	Lung Diseases (Lung Disease) 07/2013
1	Neurodevelopmental Disorders 07/2011

Drug/Important Bio-Agent (IBA)

27	MelatoninIBA 10/2022 - 02/2002
13	N- (2- (5- methoxy- indol- 3- yl)- ethyl)- 4- oxo- 4H- pyran- 2- carboxamideIBA 10/2022 - 04/2009
7	Melatonin Receptors (Melatonin Receptor)IBA 05/2016 - 02/2014
6	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 04/2009
4	Sucrose (Saccharose)IBA 01/2016 - 04/2009
3	luzindoleIBA 05/2016 - 02/2014
3	MT2 Melatonin ReceptorIBA 12/2015 - 06/2013
2	GlucocorticoidsIBA 01/2018 - 10/2017
2	Insulin (Novolin)FDA Link 05/2016 - 08/2014
2	Serotonin (5 Hydroxytryptamine)IBA 01/2016 - 06/2013
2	AntioxidantsIBA 12/2015 - 07/2013
2	Opioid Analgesics (Opioids)IBA 10/2014 - 08/2002
2	Triglycerides (Triacylglycerol)IBA 08/2013 - 04/2009
2	Antihypertensive Agents (Antihypertensives)IBA 01/2011 - 10/2006
1	Glucagon-Like Peptide 1 (GLP 1)IBA 10/2017
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2017
1	Peptides (Polypeptides)IBA 01/2017
1	Amyloid (Amyloid Fibrils)IBA 01/2017
1	Ethanol (Ethyl Alcohol)IBA 05/2016
1	Trinitrobenzenesulfonic AcidIBA 05/2016
1	mesotocin receptorIBA 05/2016
1	Antidepressive Agents (Antidepressants)IBA 01/2016
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2016
1	Serotonin 5-HT1 Receptor AgonistsIBA 01/2016
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2016
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2015
1	Neuroprotective AgentsIBA 12/2015
1	Oxygen (Dioxygen)IBA 12/2015
1	Glutamic Acid (Glutamate)FDA Link 12/2015
1	Analgesics (Analgesic Drugs)IBA 10/2014
1	Hypnotics and Sedatives (Sedatives)IBA 10/2014
1	ramelteon (Rozerem)FDA Link 09/2014
1	agomelatine (S20098)IBA 09/2014
1	tasimelteonIBA 09/2014
1	Palmitic AcidsIBA 08/2014
1	Acetic Acid (Vinegar)FDA LinkGeneric 02/2014
1	Capsaicin (Zostrix)FDA Link 02/2014
1	Naloxone (Narcan)FDA LinkGeneric 02/2014
1	Narcotic Antagonists (Opioid Antagonists)IBA 02/2014
1	SolutionsIBA 02/2014
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2014
1	Memantine (Namenda)FDA Link 01/2014
1	Hormones (Hormone)IBA 01/2014
1	Peroxidase (Myeloperoxidase)IBA 07/2013
1	Interleukin-6 (Interleukin 6)IBA 07/2013
1	CytokinesIBA 07/2013
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2013
1	Nitric Oxide Synthase (NO Synthase)IBA 07/2013
1	Free RadicalsIBA 07/2013
1	NADPH Oxidases (NAD(P)H oxidase)IBA 07/2013
1	EnzymesIBA 07/2013
1	Dexamethasone (Maxidex)FDA LinkGeneric 07/2013
1	Neu-107IBA 07/2013
1	SmokeIBA 07/2013
1	Neu-164IBA 07/2013
1	CholesterolIBA 04/2009
1	HDL CholesterolIBA 04/2009
1	Pharmaceutical PreparationsIBA 12/2007
1	6-sulfatoxymelatoninIBA 01/2004

Therapy/Procedure

6	Therapeutics 01/2014 - 01/2004
1	Ligation 10/2014